Hi Potted. Clones have no taproot. They can harbor pests and disease. Other than that, I believe clones grow as well as seeds if you have good stock. I have had equally good luck with both. The first year I grew, I grew only clones. Second year a mix of clones and seeds. Last two years seeds only. I only know one person who grows good clones, and he only grows about six strains. From a seedbank I can buy an ever increasing number of really fine strains that I can't find anywhere else. Clones are good if you want to grow lots of one particular strain. You can grow a seed and clone it, as long as it's not an auto. I suppose you could clone an auto too, but it probably wouldn't work out well. I have become a seed guy.