It would depend on what you are growing. Dung loving mushies only get pasteurized CVG while wood loving mushies get sterilized substrate. CVG grows iv done in mono tubs in the same room, inoculated pots and added a casing layer, with tub the saying gone " either you get contamination or you dry out and that's the end of that".
I did a grow last year with 2 tents, (1) with plant feeding air though a merv 13 filter to (2) a wood loving mushies tent that recycled CO2 air back to the plants and everything went great, you just got to keep a clean work area. Wood loving block, once colonized if you are getting bacterial or fungal contamination it is coming from your L/C, grains or bad transfor practice. Ones the mycelium colonized with the block you shouldn't get contamination until the blocks are spent.
I agree mycology is way groovy, symbiotic relationships between Mycorrhizae, Saprotrophic, Parasitic in environmental is a door most don't step through.