Yeah, sorry to hear about health and hope things turn around for you in that regard.
Pics would help with defol questions. I assume you are familiar with the bud based defol tutorial? I followed it closely last time, but this time I am going to remove significantly fewer leaves. Prunning leaves can help with air-flow, humidity, and expose growth to light, but I think it is easy to get carried away and trim leaves that would be better left. For my current defol I am going to take leaves that are really blocking others and I have already lollipopped, But I am going to try and keep leaves that aren't problematic (blocking others that I want to prioritize).