I'm moving from DWC to Flood & Drain, myself, though I didn't set up a drip on the DWC.
Thoughts:
On my grow I'm actually seeing slower growth than soil, I have both mediums in this grow and all are clones from the same mother which is also flowering. It wasn't really noticeable until flower and the DWC started flower showing almost 2 weeks behind the soils and remains about 2 weeks behind in bud development. Now take that with a salt mine because there are several reasons particular to my grow that may have caused this, but it honestly did catch me by surprise.
If you're using RO water make sure to check your PH and PPM as you add each nute/additive. If you're running to get a feel for what does what. I've been pretty much able to eliminate any PH up/down by taking readings and adding a bit of nutes to the res, also just plain RO.
While I do suggest changing the res the first grow or so just to get in the groove and avoid any issues, I do prefer not changing every week. I schedule changes for any major shift in nutes, especially stopping any, so like 1 at veg, 1 at 12/12 switch, and one deep in flower when ppms are being lowered. Beyond that I do a change when they've drank an equivalent of the res and brought it back down to the pump or the ppms/PH gets whacked. I'll also change if I'm noticing anything that seems related to the solution. Once you get the hang of it's really nice and allows you to give the plant what it needs.
I personally despised Hydroguard etc. It always leaves some nasty residue and I'm just not a fan. Having said that I do keep a bottle on hand in case root rot were to show up but luckily I haven't had that issue yet. I am becoming a big proponent of H2O2 though and I'll probably use that as a preventative treatment in the F&D. I'm using it now as a leaf spray and a germination solution with apparent success. No WPM and all seeds cracked, so far, lol. I also am not sure what, if any, part the LED UV has in helping stop all that stuff.
Leave a nice air space between the water level and the bottom of the netpot. I'm not sure the mechanics behind it but it did seem to make a difference in overall plant vigor. I leave about a 3-4" gap.
A lot of that is my grow specific I suppose but it's what I know
I think you'll enjoy it I did for the most part, but being limited to the netpot, etc, wasn't what I'm looking to do but I fully intend to revisit DWC again.
Best of luck and looking forward to the grow!