this last time I waited until I topped to do anything, 6 nodes, then took the bottom nodes and first leaves and the top, leaving 3 nodes. I think by this time those little leaves had already died so they were taken off. I fanned those out with stakes in a sort of manifold beginning and then took off the bottom nodes from those as the grew. now I trim fan leaves every chance I get.
so far so good. huge bushes at almost 6 weeks. I don't know if that counts as taking the brains or not but I don't think this has done anything to hinder growth.
I'm beginning to think that as long as you don't attack your plant too early and get your water/feed & environment right in the beginning so as to nurture a super healthy plant, it doesn't really matter what techniques you use. they'll grow like their genetics have already planned