If you are growing in organic soil, or a peat bases medium, then no. In soil you would wash out the nutrients, and in peat based you will have so much water in the pot it can drowned the roots.
In coco, you can water until you start to get runoff. Once runoff starts, you can assume that everything you put in after that will be adding to the amount of runoff.
The purpose of runoff is to wash out salts. If you use chemical nutrients you will get salt buildup and it will start to lower your PH. If not 'flushed' out the PH will get so low that the plant can not take up nutrients properly. The use of a 'flushing agent' compatible with your nutrient line improves the effectiveness of the flush.