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Sublingual Thread

Cool.

I'm not a student of digestion, other than knowing chewing is where it starts. The first pass/liver thing is very interesting and could explain why some people can chow down in hundreds of mgs of THC, or more, and just feel ripped off. And others take a smallish dose and are wigged out for hours.
Know thy self in that regard. It doesn't seem to be as linear as something like alcohol. Speaking of which I have a neighbor of Chinese ancestry, that can not tolerate any alcohol. Dude can't drink a beer. Some part through he gets dizzy and feels like shit. He has no enzyme for breaking alcohol down, so it goes into his blood at 100%. Or close. He's a Fee Bee, so I haven't really asked him to test my edibles. : )

My understanding of the Big Pharma under tongue drugs are those that can't survive digestion and where a direct delivery path, other than injection, is desired. Swallowing those would probably neutralize the effects or benefits.
I was talking to a friend about this. He said "Let the dude put a bit of Peruvian flake under his tongue and post about that." Its an old Wall St. trick from the '80's to keep one's nose clean. Its best not to talk in the next meeting. Just kidding of coarse.
Not.

Good luck with your tests.
 
Jason said:
I have a neighbor of Chinese ancestry, that can not tolerate any alcohol. Dude can't drink a beer. Some part through he gets dizzy and feels like shit. He has no enzyme for breaking alcohol down, so it goes into his blood at 100%.
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Alcohol dehydrogenase. Lots of people of Asian extraction seem to lack it. I used to drink with a couple of half-Japanese girls, one of whom would turn scarlet when she drank. It didn't stop her though. Teenagers...

"Let the dude put a bit of Peruvian flake under his tongue and post about that."
Click to expand...
Been there, done that. That's the substance as a hydrochloride that's very water soluble and happily numbs any mucous membrane it comes in contact with. ;) But the free base of that same substance is gummy stuff that's basically insoluble in water, kind of like our friend THC...

I have some Oleum Extracts pure THCA crystals (the un-decarbed THC acid) that should dissolve in water, but I wonder if they would be effective since that would be skipping the heating/decarb process. One sure way to find out!


Good luck with your tests.
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I have 40 drops of tincture evaporating in the kitchen right now. Fun chemistry!
 
Eating THC-A will do nothing. If you had a Lift, you could decarb it and check out the effects based on absorption.

Yeah, the Peruvian stuff, being water soluble, is a poor analog. Point was to check out the blood delivery system behind your smile.

40 drops? How many milliliters? Everything I do is measured in ml's. Also, how much flower to alcohol did you use to make the tincture?

Good luck with your tests.
 
I think your wrong ,but you can think anything you want to, I've been on Suboxone for a good many years, and if I spit out the juice it's a total waste, trust me, we have all tried that, because they don't taste good.
I can feel the Suboxone in minutes under my tongue, my Dr. Said that's the way most all medicines, will be before too long is in film form.
 
Digestion doesn't remove 80% of the THC;
"What is especially interesting about THC metabolites is that their levels in your body can be more than 10 times higher if you take cannabis in an edible form rather than through other routes (for example, smoking or vaping). "http://profofpot.com/11-hydroxy-tetrahydrocannabinol-potency-edibles/
 
> Eating THC-A will do nothing. If you had a Lift, you could decarb it and check out the effects based on absorption.
I can decarb THCA right in my vape. ;) And fresh herb on a cookie sheet in the oven (220F for 100 minutes)

> 40 drops? How many milliliters? Everything I do is measured in ml's. Also, how much flower to alcohol did you use to make the tincture?
There are about 25 drops or so of ethanol in a milliliter . The tincture is about 15 to 20 mg/ml. I don't need much to feel it, so 40 ml does the job.

Update: I put the evaporated green goo under my tongue at 3:30 and didn't swallow till 4:00 and didn't feel anything, so no rapid sublingual onset for me. After I swallowed and it got my digestive tract, effects started on the usual ( no sublingual, just swallow) schedule--slightly buzzed about an hour and a half later.
 
My second test with the Q Tip was disappointing. Not the effects I expected. Which I believe to be a strength or amount issue, not a delivery issue. So I will work on making stronger goo. Most predictable effects for edibles here, is drinking in fruit juice. 20-40 ml in V 8 does the trick.
You are correct you can decarb in a vape or oven. Read about the Nova/Lift. I have an induction digital hot plate with hot oil bath set to decarb temps. I float the flower in sealed alum. herb jars in the hot oil. So I've been doing that a while. The Lift gives me a much stronger result, ie I believe more of the THC-A is converted to THC for consumption.
Good luck with your experiments.
 
Well, eating two grams with apple sauce was a total bust. Two grams with two oz of EverClear would have been a huge dose. I don't think I'll repeat that test.

One thought does occur. The tar does not dissolve easily, although I've had some go pretty fast and other blobs seem like they want to be archived.
So I thought of melting a rice sized piece or two into a small amount of glycerin. Then put that under the tongue. So that might be the next test. Goal being to use as little glycerin as possible.
 
I'm a little confused: I thought it did work for you. And this was two grams of what? Of decarbed bud? Did you not eat any fat or oil with it?
 
Two grams of Lift decarbed Yvonna 7, a sativa dom hybrid. I decarbed about 8 grams.
I've made quite a bit of tincture with it, and it will kick your ass. Well, my ass and my friend's ass. With apple sauce, nada. Very disappointing.
No fat or oil. Just the apple sauce. And a vodka/soda chaser a bit later.
May decarb some tar I have frozen and check that out with a bit of glycerin under the tongue. Vaped, that stuff is a real sedative, so I know its packed with good stuff.
Obviously, lots to learn.
 
> You need a larger dose if you don't feel anything.
But that's just the point, eventually, about an hour and a half after I swallowed, I got a very substantial buzz. But nothing from letting it just sit under my tongue, which is why I say (again) that I think the sublingual route is bogus for cannabis. If you don't believe me, do my experiment and leave it under your tongue without swallowing and see if anything happens.
 
I responded to you above on the experiment; did you read anyone's responses? Various people suggested that THC may not absorb sublingually like other compounds.
 
I'm trying an experiment that I need some help with.
I decarbed about a gram of tar (Evaporated EverClear technique) in the Lift with a couple of ml's of glycerin. Some of the tar dissolved. The tar and glycerin was in a little round silicone container.
My question is.....should I add more glycerin to dissolve all the tar? Or just keep mashing the tar to maximize dissolving. My concern is that at some point the glycerin becomes a saturated solution and no more tar is dissolved.
The goal is to make a water soluble mix for under tongue consumption.

Or does anybody make hard candy or gummies? That could work if they are strong enough.
 
You're essentially talking oil and water--or THC and glycerin, which is about the same thing. The "tar" you are talking about is (I hope) mostly THC, which is a non-polar molecule. Glycerin is a highly polar liquid. Non-polar molecules don't dissolve in polar ones--in fact they separate. Adding more glycerin won't help.
 
Thanks for those insights.

I found this....."Vegetable glycerin may be used as a solvent and substitute for alcohol when producing botanical and herbal extracts. This is advantageous for people who wish to avoid alcohol exposure."

What is dissolved in glycerin then becomes water soluble. That's my goal.

I've read on this Forum that people use glycerin with cannabis in a crock pot to make edibles. So I just did a slight variation on that theme.

Something in the tar is definitely dissolved. The clear liquid turned dark brown. Which could easily be non THC constituents. A taste test is in store later today.

And for those of you interested in other options, glycerin is also used to make suppositories. Or so I've read. No experience on my part.
 
> Digestion doesn't remove 80% of the THC;
> "What is especially interesting about THC metabolites is that their levels in your body can be more than 10 times higher if you take cannabis in an edible form rather than through other routes (for example, smoking or vaping). "http://profofpot.com/11-hydroxy-tetrahydrocannabinol-potency-edibles/

It takes about 5 times as much THC to get my high when eating it than it does smoking it, so it's not surprising that I would have that much more metabolites in my system. BTW, "metabolites" are the leftovers--fragements, waist products--not the THC itself.

The high from edibles has a much longer "tail" for me, often lasting into the next morning (but just slightly).
 
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