I use coco/perlite. Disclosure, that is the only medium I have used except promix which is similar. Reasons, Simplicity, resistance or buffer from screw ups and unforeseen events, ease of recovery from an adverse event, low cost. Now that I have the hardware, All I need is the coco/perlite itself, cloth bags, nutrient concentrates, water, electricity, and some misc low cost expendable items. The knowledge base on this type of grow is extensive and I can read. Yes there were some bumps in the learning curve. I had an unexpected absence for 5 days at the end of the veg period last May. I was able to enlist the help of friends and provide them with explicit instructions on mixing the solutions. All they had to do was measure, mix, pour, and remove runoff. If I had been running a DWC system (an option I seriously considered) I don't think the grow would have survived. The bottom line is, do what works for you, and the harvest results.