I am a soil grower. FFOF and 20% perlite. I feed at 6.2 - 6.5.
When I have pushed the ph low (I blame it on the good weed) I have had the mottled brown spots. Not like yours that are all over all plants, but in a pot that got mottled and sick. My tap water is 8.5-8.8 untreated but I got too aggressive with the adjuster. A few days of H2O from the tap (short of a flush) and a little calmag and we could see clean new growth.
I do not believe that the medium is the big factor, she won't take up the cal if the ph is too low.