I have never had a problem adding PH up directly to my res. Pro-tekt, on the other hand is very high in Potassium Silicate, which will cause other ingredients in your solution to precipitate and thus should never be added to res. When mixing new Nutrients, always add the Pro-tekt first. PH up also contains potassium silicate, but at a much lower level with added ingredients such as potassium carbonate to act as buffers to try to prevent reactions.