One would think so, like i said, plant matter doesnt just dissapear. Even when specific plant material dies, there is always fibre leftover. Pests can come from anywhere, even if your grow room is sealed (though a lot less likely).
Moths spawn caterpillars so their mobility is massive.
I have experience with organic sprays so if you want to try some, here are my favorites.
Pyrethrum:
Very weak, natural plant based, best for as a preventative. Doesnt do very well at killing pests but is ok as a protective agent against new pests.
Natrasoaps:
Made from natural products which is low toxic and works well on common bugs such as whiteflies, aphids, mites.
A good broad spectrum.
Neem oil:
Said to work against caterpillars, i used this and never had a problem since. Had to use a couple of times but is my favorite when natrasoaps dont work. Seems to cover a different sort of pests.
Copper oxychloride (spray)
Disputed wether its "organic" but its close enough, used for fungus, mold, powdery mildew.
But yea, you only need one tinsy caterpillar to have problems.