Just a quick note from an organic grower (which it sounds like you are...partly). If you're growing organic (without synthetic nutes/supplements), it can be very detrimental to add things like cal/mag or other supplements. When you're going for an organic grow, you take care of the soil biome. This means that all you do is take care of the fungi and bacteria which in turn take care of the soil which then takes care of the plant. Oftentimes, synthetic additions can kill off those beneficial microbes which cause a deficiency or toxicity.
It also sounds like you may be pH-ing your water. With organic grows, that can be detrimental for the same reason - pH up and down have chemicals in them that damage the soil biome which begins a domino effect ending in the plant showing symptoms. When growing organic, the microbes manage the pH for you. Afterall, when was the last time you saw a farmer out pH-ing raindrops as they fell from the sky? If you do end up having to pH your water, use organic methods - baking soda for pH up, and lemon juice or white vinegar for pH down.
You mentioned that you've done multiple autoflowers in the same setup and they have done well. With autoflowers, they're usually done in a total of a few months whereas photos tend to take longer. This means that photos have more opportunity for things to go a little off-kilter meaning that deficiencies/toxicities have more time to show themselves or at least to progress far enough to show symptoms.
They don't look like they're in the flowering stage yet, so I would let them be for a little bit. Make sure you're not overwatering (VERY EASY in organic soil!), make sure temp/humidity are in check, and see if that stops the problem from progressing. Note that the brown spots will not turn green again, so the goal is to stop the progression, not turn brown back to green. It may take a week or longer, so be patient. The good thing is that if you are still in veg stage, you can delay the flip for as long as you need to.
Also, if you are going to proceed assuming that there is a deficiency, try using epsom salt in your next watering or as a foliar spray. See
https://www.growweedeasy.com/wp-content/uploads/2010/04/magnesium-info-marijuana.jpg
Good luck!