Joker-I will give you my experience. I have been dealing with severe anxiety since my early twenties. There was a year in my life that I went outside maybe six times. It has been a ride and I have great empathy for your wife and you trying to find some treatments. The shit they gave me from doctors either turned me into a zombie or I had really bad reactions, so they can keep their chemical crap. I have found relaxation exercises to be the best short term defense, but takes years to develop. I am in my mid fifties and this is still my main health issue.
Three years ago, I decided to investigate if cannabis could help me be more stable and happy. I found that it certainly did, but not completely. I have found, like the advice you have gotten, that Indica dominate strains work best. Also, I have found that letting the tricomes go a little amber produces a more relaxing high. My problem is that I get used to a strain quickly and it is less effective for me so I try to grow as many different strains as possible. I have found that Kush strains and even spefically Afghan Kush work well for me. I look for strains closer to landrace as possible. I like Master Kush and Northern Lights, but there are other hybrids that have worked too. I am constantly hunting for the "perfect" strain and having fun trying to grow it.
Here is another thing I have discovered that helps is to vape! I got a vaporizer that you can control temperatures and found a setting that will literally melt anxiety from the top of your head down. I use it when I need to go deal with the public and combust when I am staying home. Am I cured? No, but I am much happier and my wife thinks I am a much better person to be with, plus I am a "productive" person in society.
My advice is to go to Leafly and look up strains for anxiety and read reviews on them with your wife. If she is not a regular consumer that may be an initial problem too. It took me at least a month of regular smoking to reduce the natural paranoia from smoking the powerful strains available today. Be patient, it might take time to find what works but don't give up. I believe that cannabis has helped me achieve a balance in my life. Sorry to ramble but this hit home and thought my experience may help. I wish you and your wife the best in your quest.