Here's my two cents...
Growers often get excited about chasing numbers like VPD, PPFD, EC, and a host of other acronyms. These are all very important and can be very helpful and effective tools/measurements....if you have everything else dialed in. And guess what? If you have temps and RH dialed in, you're probably within an acceptable VPD. Temp/RH and VPD are all connected with each other and Temp/RH are what create the VPD.
So, my advice is to focus on temp and RH first and foremost. If that keeps your plants happy and growing healthy, then pat yourself on the back since you've done 90% of what you need to do! If your plants are happy and healthy, then feel free to try dialing in a VPD if you feel like it. But then again, if your plants are happy and healthy, why fiddle with things - if it's not broke, don't fix it! If your plants aren't happy, you need to start with the basics - back to temp and RH...and ventilation, circulation, watering regime, lighting, and nutrients as opposed to concerning yourself with VPD.
And don't forget, VPD is based on LEAF temps, not air temps. So to measure an accurate VPD, you need to have a way to accurately measure the leaf temperature, otherwise your VPD number that you get will be inaccurate and unhelpful at best and detrimental at worst.
Basically, all the fancy calculus is helpful as long as you have everything else under control. Many growers will never need to focus on things like VPD because they have enough work to do managing temps and humidity in a homegrow environment. Managing VPD is more of a graduate-level activity. But before focusing on things like that, one should have the basics mastered with an understanding of how changing temps affect relative humidity, etc.