I am not a mechanical engineer and can only base this on my experience in the fire service with its use. If I have a house full of smoke and I use positive pressure I can clear the home twice as fast as neg pressure. Putting a ventilation fan at a distance to encapsulate the opening of the front door charges the building(positive Pressure) and allows a larger CFM of air to move through and clear the building. By opening or closing any openings, interior or exterior, you can control air movement to the exterior changing the CFM. The more openings the more air movement as long as the air coming in does not drop to an equal pressure. (Too many openings). If I put a fan in a window and pull, suck, create a vacuum air out, you can only move what the fan will allow through that window. If you have to many openings you lose neg pressure and air flow reduces. If you close more openings the neg pressure increases but will still only move what the fan allows through that opening. Negative pressure on a fan reduces its efficiency until you allow some type of air flow in to it. Working at a refinery the buildings are positive pressurized so nothing from the outside gets inside. This is not about air flow it is strictly about maintaining a positive pressure for health reasons. Air movement is minimal until you have an opening, then it increases such as opening a door. Science may say different but from my experience positive pressure moves more CFM than Negative, its all how you use them. As I said, I have no degree, only what I have learned from my experience JMO.