There are hundreds of heirloom fruits and vegetables you only see in the seed catalogs with unique flavors or visual appeal. Totally unavailable in a grocery store - because big "Farma" can't industrialize the plant (S to H too long, hard to transport, lower yields, etc.).
To some extent, this is happening to cannabis. One commercial cannabis greenhouse in AZ has over 40, yes forty, acres under glass. Commercial growers have to focus on strains that mature, dry and cure uniformly and have bud characteristics (density, sparkle, color, odor) currently in demand. How their seeds genetics are affected in a non-highly controlled environment are of zero concern. Outdoor, home growers will need to pay particular attention to matching
strain genetics to their local climate and pick " boutique" varieties that have evolved to survive in that weather's pathogens.
Remember, like a real high fence can help deer proof a grow; botrytis and WPM resistant strains can save the harvest.